Prophylactic Treatment of Endotoxic Shock with Monophosphoryl Lipid A in Newborn Rats
نویسندگان
چکیده
منابع مشابه
modern surgical techniques in treatment of patients with cleft lip & cleft palate
چکیده ندارد.
15 صفحه اولInteraction of melittin with endotoxic lipid A.
Several amphipathic and cationic substances are known to bind lipid A, the toxic component of bacterial lipopolysaccharides. In this report, we have characterized, by fluorescence methods, the interaction of melittin, an amphipathic and basic 26-residue polypeptide isolated from bee venom, with lipid A. The stoichiometry of the complex appears to be two molecules of melittin to one of lipid A w...
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Background: Generation of monocyte-derived dendritic cells (MDDC) is induced in the presence of GM-CSF and IL-4, and a maturation stimulus is added to the monocyte culture to obtain mature Dendritic Cells (DCs) suitable for therapy. TNF-α is the most common cytokine used for activating DCs and generating mature MDDC either alone or in combination with other cytokines. Objective: To compare effe...
متن کاملBacteraemic and endotoxic shock.
In 1924 Sanarelli recorded that endotoxins of Gram-negative organisms would damage capillary and postcapillary venular endothelium. By 1935 it was known that two spaced doses of endotoxin given to rabbits would cause renal cortical necrosis and foci of damage in many organs, the Shwartzman reaction. This is due to a combination of vasospasm and intravascular coagulation. Human equivalents of th...
متن کاملDistinct Patterns of Wnt3a and Wnt5a Signaling Pathway in the Lung from Rats with Endotoxic Shock
Septic shock is a syndrome with severe hypotension and multiple organ dysfunction caused by an imbalance between pro-inflammatory and anti-inflammatory response. The most common risk factor of acute lung injury is severe sepsis. Patients with sepsis-related acute respiratory distress syndrome have higher mortality. Recent studies reveal regulatory roles of Wnt3a and Wnt5a signaling in inflammat...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1999
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199904020-01059